2012 Science and Environment Medal Recipient Neal A. Young

2012 Science and Environment Medal Recipient

This medal recognizes a federal employee for a significant contribution to the nation in activities related to science and environment (including biomedicine, economics, energy, information technology, meteorology, resource conservation, and space).

Neal S. Young

Position: Chief of the Hematology Branch, National Heart, Lung and Blood Institute

Agency: National Institutes of Health

Location: Bethesda, Maryland

Achievement: Saves lives through cutting-edge research and treatments for patients with bone marrow failure diseases, including the rare and once deadly blood disorder known as aplastic anemia.

 

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Infusing New Life

For years, patients with severe aplastic anemia died within months of developing the rare blood disease. Dr. Neal Young has increased the survival rate to 80 percent—and climbing.

Dr. Neal Young is the world’s leading expert in the field of bone marrow failure, engaging in groundbreaking research that has led to life-saving treatments for a rare and deadly blood disorder known as aplastic anemia.

In his work at the National Institutes of Health (NIH), Young has combined pioneering basic laboratory science, clinical research protocols, and direct patient care to save the lives of thousands of people suffering from a blood disorder that wipes out the cells in the bone marrow, including red blood cells that carry oxygen, white blood cells that fight infection and platelets that help clot the blood.

Young conceived, designed and headed the first multicenter clinical trial in the United States for immunosuppressive therapy for aplastic anemia. The regimen he developed for this blood disease has become standard therapy for patients all over the world. This disease strikes about 600 to 900 people a year in the United States, and thousands across the globe.

“Neal has completed an amazing series of landmark clinical trials and published results that have taken what was a fatal disease in the early 1980s to one that now has a survival rate of 80 percent or more in the long-term,” said Dr. Cynthia Dunbar of the National Heart, Lung and Blood Institute at NIH.

Because of Young’s efforts, his clinic at NIH is today considered one of the world’s major referral centers for patients with bone marrow failure syndromes, including aplastic anemia. His clinic follows many hundreds of patients from North and South America, Asia and Africa.

One of them is Jordan Culbreath, a Princeton University football player diagnosed with aplastic anemia in 2009, during his junior year. Not only was Culbreath cured, but he was able to return to the field his senior year after Young treated him.

As chief of the Hematology Branch of the National Heart, Lung and Blood Institute, Young is continually building on his significant accomplishments. He developed an understanding of how the highly contagious B19 parvovirus infects cells of the bone marrow and showed its role in disease among patients, especially those with sickle cell anemia and others with defective immune systems. He developed ways to test for and diagnose this virus, came up with a treatment and currently has a vaccine in clinical trials that, if successful, will protect vulnerable patients.

Young also has made landmark discoveries linking genetic defects—mutations or mistakes in the DNA sequence—to the break down in cells and as a cause of aplastic anemia. He has determined through laboratory tests that sex hormones can prevent the cell damage, and he is now moving these findings into human clinical trials.

In addition, Young has implicated the same type of genetic mutations linked to aplastic anemia much more broadly to liver cirrhosis, lung fibrosis and leukemia. These findings may offer clues to improving treatment and patient outcomes for these common and devastating diseases.

Dr. Ching-Hon Pui, chairman of the Department of Oncology at St. Jude Children’s Research Hospital in Tennessee, said Young’s work in hematology “has totally transformed the field.”

“His impact has been truly global,” said Pui. “I cannot think of another hematologist with comparable accomplishments.”

Dr. Robert Gallo, a biomedical researcher who played a major role in the discovery of the virus that causes AIDS, said Young is “at the forefront of the field of aplastic anemia.” He said Young has made significant contributions at the “fundamental research level, in the clinical setting and at the therapeutic level.”

In addition to heading the NIH Hematology Branch, Young is the director of the NIH Center for Human Immunology, Autoimmunity and Inflammation. This center is dedicated to gaining a better understanding of how the immune system and inflammation affect a wide variety of common disorders, including cancer, atherosclerosis, rheumatic syndromes and neurologic degeneration. The center pulls in NIH experts from a wide variety of disciplines to share information and find commonalities that might help spur new treatments.

The Service to America Medals are presented annually by the nonprofit, nonpartisan Partnership for Public Service to celebrate excellence in our federal civil service.

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